Dr. Susan Thomas



 

 

 

 

 

 

 

 

Scientist 'D'

susan

Biomedical Informatics Centre
Phone : +( 91-22) 2419 2104
Email  : thomass@nirrh.res.in


Academic Background

  • M.Sc. Tamil Nadu Agricultural University (Biotechnology; 1998)
  • Ph.D Indian Institute of Technology , Bombay (Biotechnology; 2007)


Professional Experience

Scientist NIRRH 2006 - Till date

 


Research Interests

  • Sequence-structure-function relationship of proteins
  • Identification of novel targets for diseases
  • Identification of cell-specific homing peptides
  • Gene-disease associations


Awards & Achievements

  • Scholarships/Fellowships
    • Indo-US Science and Technology Forum Research Fellowship (2011 – 2012)
    • Fulbright PDR scholarship (selected but not availed)
    • SERC Fast Track Scheme for Young Scientists (2010-2013)
    • Junior & Senior Research Fellowship from CSIR (2001 - 2006)
    • Junior Research Fellowship from ICAR (1996-1998)
    • KAU merit scholarship (1991-1996 )
  • Achievements
    • Gargi Vishnoi Memorial Award - Best Ph.D Thesis of BioSchool, IITB, 2007
    • Finn Wold Travel Awardee of Protein Science Society, USA - 2006
    • National Eligibility Test (NET) – 2001
    • State Eligibility Test (SET) -2001

Publications
(Last 10)

1. Joseph S, Barai RS, Bhujbalrao R, Idicula-Thomas S. (2015) PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome. Nucleic Acids Res.

2. Waghu FH, Barai RS, Gurung P, Idicula-Thomas S. (2015) CAMPR3: a database on sequences, structures and signatures of antimicrobial peptides. Nucleic Acids Res.

3. Gokhale P, Mania-Pramanik J, Sonawani A, Idicula-Thomas S, Kerkar S, Tongaonkar H, Chaudhari H, Warke H, Salvi V. (2014) Cervical cancer in Indian women reveals contrasting association among common sub-family of HLA class I alleles. Immunogenetics.

4. Pandit H, Gopal S, Sonawani A, Yadav AK, Qaseem AS, Warke H, Patil A, Gajbhiye, R, Kulkarni V, Al-Mozaini MA, Idicula-Thomas S, Kishore U, Madan T. (2014) Surfactant Protein D Inhibits HIV-1 Infection of Target Cells via Interference with gp120-CD4 Interaction and Modulates Pro-Inflammatory Cytokine Production. PLoS One. 9(7):e102395

5. Gokhale PS, Sonawani A, Idicula-Thomas S, Kerkar S, Tongaonkar H, Mania-Pramanik J. (2014) HPV16 E6 variants: Frequency, association with HPV types and in silico analysis of the identified novel variants. J Med Virol. 86 (6), 968-974

6. Waghu F.H., Gopi, L., Barai R.S., Ramteke, P, Nizami B, Idicula-Thomas S. (2014) CAMP: Collection of sequences and structures of antimicrobial peptides Nucleic Acids Res. 42 (D1), D1154-D1158

7. Sonawani A, Niazi S, Idicula-Thomas S. (2013) In silico study on binding specificity of gonadotropins and their receptors: design of a novel and selective peptidomimetic for human follicle stimulating hormone receptor. PLoS One. 8(5):e64475.

8. Wolfe LM, Veeraraghavan U, Idicula-Thomas S, Schurer S, Wennerberg K, Reynolds R, Besra GS, Dobos KM. (2013) A Chemical Proteomics Approach to Profiling the ATP-Binding Proteome of Mycobacterium tuberculosis. Mol Cell Proteomics. 12 (6), 1644-1660

9. Joseph, S., Karnik, S., Nilawe, P., Jayaraman, V.K., Idicula-Thomas S. (2012) ClassAMP: a Prediction Tool for Classification of Antimicrobial Peptides. IEEE/ACM Trans Comput Biol Bioinform. PMID: 22732690. (IF*: 2.25)

10. Mistri, M, Tamhankar, P.M., Sheth, F., Sanghavi ,D., Kondurkar, P., Patil, S., Idicula-Thomas, S., Gupta, S., Sheth, J. (2012) Identification of Novel Mutations in HEXA Gene in Children Affected with Tay Sachs Disease from India. PLoS One. PMID: 22723944 (IF*: 4.4)

Present Students

1. Fayza Waghu
2. Kaushiki Prabhudesai
3. Mohammed Husain Bharmal

Projects (Ongoing)

1. Analysis of the structures of known antimicrobial peptides using machine learning algorithms and molecular dynamics simulations (Department  of Science and Technology; 2013-2016)

2. Exploring the hinge and transmembrane region of human FSHR for design of small molecule and peptidomimetic modulators (Department of Biotechnology; 2015-2018)

 

Projects (Completed)  

  • Elucidation of role of primary structure of proteins on their antimicrobial activity. .(Funded by DST)
  • Introduction of electronic patient record systems in Indian government hospitals. .(Funded by DST)
  • Studies to understand the tertiary structure-dependence on antimicrobial activity of 2 novel peptides. .(Funded by DST)