Dr. Smita Mahale



 

 

 

 

 

 

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Scientist 'G' & Director

Division of Structural Biology
Phone : +( 91-22) 2419 2002
Email  : mahales@nirrh.res.in

Academic Background

  • M.Sc. University of Mysore (Biochemistry; 1980)
  • Ph.D University of Mumbai (Biochemistry; 1992)

Professional Experience

Scientist NIRRH 1981 - Till date

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Research Interests

  • Structure-function relationship of gonadotropins and gonadotropin receptors
  • Structure-function relationship of prostate secretory protein 94

Awards & Achievements

  • Department of Biotechnology Overseas Associateship (long-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 1996-1997

  • ICMR Swaran Kanta Dingley Award 2005

  • Department of Biotechnology Overseas Associateship (short-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 2007

  • Received Labhsetwar Award for the year 2009, constituted by Drs. Lata and Anant Labhsetwar Foundation, USA and Labhsetwar Charitable trust, Nagpur for the scientific contribution in the area of gonadotropin research. The award was conferred during the International Conference on Reproductive Health and 20th Annual Meeting of the Indian Society for the Study of Reproduction and Fertility held at Jaipur from 8-10 February, 2010.

  • Elected as a Fellow of the National Academy of Sciences, India. 2010.

Publications (Last 10)

  1. Mhatre DR, Mahale SD, Khatkhatay MI, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Desai MP, Dandekar SP, Varadkar AM (2014). Development of an ELISA for sPSP94 and utility of the sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer. Clin Chim Acta436C : 256-262. (IF: 2.748)

  2. Desai SS, Roy BS, Mahale SD (2013). Mutations and polymorphisms in FSH receptor: Functional implications in human reproduction. Reproduction 146, R235-R248 (IF: 3.55).

  3. Desai SS, Achrekar SK, Paranjape SR, Desai SK, Mangoli VS, Mahale SD (2013). Association of allelic combinations of FSHR gene polymorphisms with ovarian response. RBM Online27, 400-406    (IF: 2.675).

  4. Navalakhe RM, Jagtap DD, Nayak SU, Nandedkar TD, Mahale SD (2013). Effect of FSH receptor binding inhibitor-8 (FRBI-8) on FSH mediated granulosa cell signaling and proliferation. Chem Biol and Drug Des. 82, 178-188 (IF: 2.282).

  5. Anklesria JH, Jagtap DD, Pathak BR, Kadam KM, Joseph S, Mahale SD (2013). Prostate secretory protein of 94 amino acids (PSP94) binds to prostatic acid phosphatase (PAP) in human seminal plasma. PLoS One. 8(3):e58631  (IF: 4.091). 

  6. Breed AA, Gomes A, Sur Roy B, Mahale SD, Pathak BR (2013). Mapping of the binding sites involved in PSP94-CRISP-3 interaction by molecular dissection of the complex. BBA Gen. 1830, 3019-3029 (IF: 5.00).

  7. Nandedkar TD*, Sagvekar P, Thakur B, Navlakhe R, Chitnis S, Mahale SD, D’Souza S, Patel KD, Vavia PR (2013). Polymeric nanoparticle formulation of Octapeptide (NP-OP): In vitro release and in vivo effect in common marmosets, Callithrix jacchus Linn. Indian Journal of Experimental Biology. 51, 1055-1062   (IF: 1.195).

  8. Dupakuntla M, Pathak BR, Sur Roy B, Mahale SD (2012).  Extracellular loop 2 in the FSH receptor is crucial for ligand mediated receptor activation.  Mol Cell Endocrinol. 362: 60–68. (IF: 4.119)

  9. Desai SS, Achrekar SK, Pathak BR, Desai SK, Mangoli VS, Mangoli RV and Mahale SD (2011).  Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in granulose cells.  J. Clin. Endocrinol. Metab. 96, 2805-2812.  (IF: 6.438)

  10. Pathak BR, Breed AA, Nakhawa VH, Jagtap DD and Mahale SD (2010).   Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific. Asian J. Androl. 12, 677-689. (IF: 1.679)

Present students

  • Ms. Swapna Desai
  • Ms. Jenifer Anklesaria
  • Ms. Susha Kutteyil
  • Ms. Antara Banerjee
  • Mr. Ram Barai
  • Ms. Shaini Joseph

Past student

  • Dr. Pallavi Kene
  • Dr. Jeevan Ghosalkar
  • Dr. Swati Achrekar
  • Dr. Suman Jagtap
  • Dr. Madhavi Dupakuntla

Projects Completed

  • Identification of ligand binding regions on the extracellular domain of human follicle stimulating hormone receptor (Funded by Board of Research in Nuclear Sciences, 2000-2003)

  • Studies on the structure-function relationship of human follicle stimulating hormone using disulphide peptides of its β-Subunit (Funded by Department of Science & Technology, 2001-2004)

  • Mutational analysis of human gonadotropin receptor genes and its implications in physiology and pathophysiology of pituitary gonadal axis (Funded by ICMR, 2002-2005)

  • Follicle stimulating hormone receptor: Molecular mechanisms involved in its activation and signal transduction (Funded by Board of Research in Nuclear Sciences, 2005-2008)

  • Human beta microseminoprotein: Studies on structural characterization and understanding its role in modulation of follicle stimulating hormone and sperm function (Funded by Department of Biotechnology, 2005-2008).

  • Biomedical Informatics Centre of ICMR Phase I (Funded by Indian Council of Medical Research, 2006-2012).

  • Implication of follicle stimulating hormone signaling in prostate pathophysiology (Funded by ICMR, 2007-2010).

  • Expression of follicle stimulating hormone receptor in granulosa cells and its association with altered ovarian response to gonadotropin treatment (Funded by Board of Research in Nuclear Sciences, 2009-2012).

  • Surface accessibility of extracellular loops of follicle stimulating hormone receptor and their role in ligand-receptor interaction (Funded by Department of Science & Technology, 2010-2013).

Projects Ongoing

  • Biomedical Informatics Centre of ICMR Phase II (Funded by Indian Council of Medical Research, 2013-2018).

  • Callithrix jacchus FSH: Production of Recombinant Protein and Understanding the Gene Regulation (Funded by Department of Biotechnology)

  • Role of Specific Residues in the Follicle Stimulating Hormone Receptor in its Function

  • PSP94 Interactome: Identification and characterization of its novel binding proteins from human seminal plasma and sperm (Funded by Board of Research in Nuclear Sciences)