.

Scientist 'E'

Division of Structural Biology
Phone : +( 91-22) 2419 2015
Email  : mahales@nirrh.res.in

Academic Background

Professional Experience

.

Research Interests

Awards & Achievements

• Department of Biotechnology Overseas Associateship (long-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 1996-1997

• ICMR Swaran Kanta Dingley Award 2005

• Department of Biotechnology Overseas Associateship (short-term) for carrying out research at Wadsworth Center, New York State Department of Health, Albany, New York, USA : 2007

• Received Labhsetwar Award for the year 2009, constituted by Drs. Lata and Anant Labhsetwar Foundation, USA and Labhsetwar Charitable trust, Nagpur for the scientific contribution in the area of gonadotropin research. The award was conferred during the International Conference on Reproductive Health and 20th Annual Meeting of the Indian Society for the Study of Reproduction and Fertility held at Jaipur from 8-10 February, 2010.

• Elected as a Fellow of the National Academy of Sciences, India. 2010.
  

Publications (Last 10)

1. S. S. Chitnis, C. Selvakumar, D. D. Jagtap, R. P. Barnwal, K. V. R. Chary, S. D. Mahale and T. D. Nandedkar. Interaction of GRBI-8, a Novel Follicle Stimulating Hormone Binding Inhibitor with FSH and its Receptor. Chem Biol andDrug Design73, 637-643, 2009.

2. S. K. Achrekar, D. N. Modi, S. K. Desai, V. S. Mangoli, R. V. Mangoli, S. D. Mahale. Poor ovarian response to gonadotropin stimulation is associated with SNP in the 5’ untranslated region of FSH receptor. RBM Online 18, 509-515, 2009.

3. M. Kumar, D. D. Jagtap, S. D.Mahale, V. Prashar, A. Kumar, A. Das, S. C. Bihani, J. L Ferrer, M. V. Hosur, M. Ramanadham. Crystallization and preliminary X-ray differaction analysis of human seminal plasma protein PSP94. Acta Crystallogr. 65, 389-391, 2009.

4. M. Dupakuntla, J. D. Ghosalkar and S. D. Mahale. Characterization of peptide 20-30 of follicle stimulating hormone receptor as an antagonist of receptor activity: Significance of charged residues. Chemical Biology and Drug Design 73, 108-114, 2009.

5. S. K. Achrekar, D. N. Modi, S. K. Desai, V. S. Mangoli, R. V. Mangoli, S. D. Mahale. Follicle-stimulating hormone receptor polymorphism (Thr 307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women. Fertility & Sterility 91, 432-439, 2009.

6. S. S. Chitnis, R. M. Navlakhe, G. C. Shinde, S. J. Barve, S. D’Souza, S. D. Mahale and T. D. Nandedkar. Granulosa cell apoptosis induced by a novel FSH binding inhibitory peptide from human ovarian follicular fluid. J. Histochem. Cytochem. 56, 961-968, 2008.

7. J. D. Ghosalkar, S. J. Dharma, T. D. Nandedkar and S. D. Mahale. Identification of the region 285-309 of follicle stimulating hormone receptor as a bioneutralizing epitope. J. Reprod. Immunol. 74, 24-33, 2007.

8. D. D. Jagtap, A. Narahari, M. J. Swamy and S. D. Mahale. Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin. Biochim. Biophys. Acta. 1774, 723-731, 2007.

9. P. R. Wadia , S. D. Mahale, T. D. Nandedkar. Effect of the human follicle-stimulating hormone-binding inhibitor and its N-terminal fragment on follicle-stimulating hormone-induced progesterone secretion by granulosa cells in vitro. J. Biosci. 32, 1185-1194, 2007.

10. Das, V. Prashar, S. D. Mahale, L. Serre, J. L. Ferrer and M. V. Hosur. Crystal structure of HIV-1 protease in situ product complex and observation of a low-barrier hydrogen bond between catalytic aspartates. PNAS 103, 18464-18469, 2006.

Present students

Past student

Projects

• Human beta microseminoprotein: Studies on structural characterization and understanding its role in modulation of follicle stimulating hormone and sperm function ( Funded by Department of Biotechnology)

• ICMR Biomedical Informatics Centre ( Funded by Indian Council of Medical Research)

• Implications of follicle stimulating hormone signaling in prostate pathophysiology ( Funded by ICMR Medical Innovation Fund)

• Expression of follicle stimulating hormone receptor in granulosa cell and its association with altered ovarian response to gonadotropin treatment ( Funded by Board of Research in Nuclear Sciences, Department of Atomic Energy)