National Center for Preclinical Reproductive and Genetic Toxicology

About Us







National Center for Preclinical Reproductive and Genetic Toxicology was jointly established at the institute by the Department of Science and Technology (DST) and Indian Council of Medical Research (ICMR). Reproductive and genetic toxicology studies of new molecules following Good Laboratory Practices (GLP), are mandatory before initiation of clinical trials. The center is one among the few centers in the country that undertakes comprehensive research and testing of new molecules for pre-clinical reproductive and genetic toxicity. We are presently studying the d evelopmental effects of e xposure to Bisphenol A, an endocrine disrupter, on hypothalamus, pituitary and testicular axis in neonatal rats.

Objectives of the center

  • To undertake preclinical reproductive and genetic toxicological evaluations of test compounds following Good Laboratory Practice (GLP).

  • To delineate the mechanism of action of test compounds at cellular and molecular level using in vitro assays and by introducing newer approaches like epigenomics, toxicogenomics and proteomics etc, to investigate toxic manifestations of the compound.

  • To provide services to public and private sectors at the national level and act as a national reference center on reproductive and genetic toxicology.

  • To create a cadre of the researchers with expertise in the area of reproductive and genetic toxicology by organizing periodic (twice a year for three years) hands-on workshops/training courses/orientation programs with special emphasis on the related techniques in accordance with GLP regulations .

  • To disseminate information on reproductive and genetic toxicology by organizing symposium, seminars and through publications.